Anti-Adeno-Associated Virus Antibodies

Anti-AAV antibodies are suitable for characterization of different stages of infection and very useful for the analysis of the AAV assembly process. The antibodies specifically react with intact adenoassociated virus particles, empty and full capsids and recognize a conformational epitope of assembled capsids.

Anti-Adeno-Associated Virus Capsid Proteins Antibodies

The antibodies are suitable for detection of several adeno-associated virus capsid proteins and virus particles.

Anti-Adeno-Associated Virus Capsid Proteins Antibodies - Sample Size

The following antibody is available in sample size of 10µg (lyophilized).

Anti-Adeno-Associated Virus Particle Antibodies

Potential Binding Sites of the ADK1a/1b Antibody

The ADK1a antibody used for the AAV1 Titration ELISA as well as the ADK1b specifically recognize assembled AAV1 capsids, hence epitopes that result from a specific conformational assembly of the capsid proteins VP1, VP2 and VP3. In the publication cited below the contact sites and footprint residues identified for ADK1a and ADK1b are described and the results are summarized in table 1. Multiple contact sites and footprint residues have been identified, that are very likely to be part of the binding site. The amino acids of each binding site are located in different parts of the protein chains and are recognized as the epitope of the antibody only in the assembled capsid where they are in close proximity to each other and in the correct conformation.

Neutralization epitope of the ADK1 Antibody

For AAV1 the neutralization epitope has been identified and might give an additional indication about the binding residues of the neutralizing antibody ADK1 used for the corresponding AAV1 Titration ELISAs.

anti-AAV1 (intact particle) mouse monoclonal, ADK1a, lyophilized, purifiedCat. No. 610150
anti-AAV1 (intact particle) mouse monoclonal, ADK1a, lyophilized, purified, sampleCat. No. 610150S
anti-AAV1 (intact particle) mouse monoclonal, ADK1a, Biotin ConjugateCat. No. 615150

Potential Binding Sites of the A20 Antibody

The A20 and A20R antibodies used for the AAV2 Titration ELISAs (PRATV & PRAAV2R) specifically recognize assembled AAV2 capsid, hence epitopes that result from a specific conformational assembly of the capsid proteins VP1, VP2 and VP3. Several publications cited below describe the analysis of binding sites for the A20 antibody using different techniques. Multiple amino acids have been identified, that are very likely to be part of the binding site, especially those that were identified with more than one method (green boxes). The amino acids of each binding site are located in different parts of the protein chains and are recognized as the epitope of the antibody only in the assembled capsid where they are in close proximity to each other and in the correct conformation.

anti-AAV2 (intact particle) mouse monoclonal, A20, lyophilized, purifiedCat. No. 61055
anti-AAV2 (intact particle) mouse monoclonal, A20, lyophilized, purified, sampleCat. No. 61055S

anti-AAV2 (intact particle) mouse monoclonal, A20, Biotin Conjugate

Cat. No. 61555
anti-AAV2 (intact particle) mouse monoclonal, A20, supernatantCat. No. 65155
anti-AAV2 (intact particle) mouse recombinant, A20R, lyophilized, purifiedCat. No. 610298
anti-AAV2 (intact particle) mouse recombinant, A20R, lyophilized, purified, sampleCat. No. 610298S
anti-AAV2 (intact particle) mouse recombinant, A20R, Biotin ConjugateCat. No. 615298
anti-AAV4 (intact particle) mouse monoclonal, ADK4, lyophilized, purifiedCat. No. 610147
anti-AAV4 (intact particle) mouse monoclonal, ADK4, lyophilized, purified, sampleCat. No. 610147S
anti-AAV4 (intact particle) mouse monoclonal, ADK4, Biotin ConjugateCat. No. 615147  

Potential Binding Sites of the ADK5a/5b Antibody

The ADK5a  antibody used for the AAV5 Titration ELISA as well as the ADK5b specifically recognize assembled AAV5 capsids, hence epitopes that result from a specific conformational assembly of the capsid proteins VP1, VP2 and VP3. In the publication cited below the contact sites and footprint residues identified for ADK5a and ADK5b are described and the results are summarized in table 1. Multiple contact sites and footprint residues have been identified, that are very likely to be part of the binding site. The amino acids of each binding site are located in different parts of the protein chains and are recognized as the epitope of the antibody only in the assembled capsid where they are in close proximity to each other and in the correct conformation.

anti-AAV5 rabbit polyclonal, serumCat. No. 610137
anti-AAV5 (intact particle) mouse monoclonal, ADK5a, lyophilized, purifiedCat. No. 610148
anti-AAV5 (intact particle) mouse monoclonal, ADK5a, lyophilized, purified, sampleCat. No. 610148S
anti-AAV5 (intact particle) mouse monoclonal, ADK5a, Biotin ConjugateCat. No. 615148
anti-AAV5 (intact particle) mouse monoclonal, ADK5b, lyophilized, purifiedCat. No. 610149
anti-AAV5 (intact particle) mouse monoclonal, ADK5b, lyophilized, purified, sampleCat. No. 610149S
anti-AAV6 (intact particle) mouse monoclonal, ADK6, lyophilized, purified Cat. No. 610159
anti-AAV6 (intact particle) mouse monoclonal, ADK6, lyophilized, purified, sample Cat. No. 610159S

Potential Binding Sites of the ADK8 Antibody

The ADK8 antibody used for the AAV8 Titration ELISA (PRAAV8) specifically recognizes assembled AAV8 capsid, hence epitopes that result from a specific conformational assembly of the capsid proteins VP1, VP2 and VP3. The publication cited below shows the result of the Cryo-EM analysis of binding sites for the ADK8 antibody. In this publication one potential epitope has been identified which is likely to be part of the ADK8 binding site.

anti-AAV8 (intact particle) mouse monoclonal, ADK8, lyophilized, purifiedCat. No. 610160
anti-AAV8 (intact particle) mouse monoclonal, ADK8, lyophilized, purified, sampleCat. No. 610160S
anti-AAV8 (intact particle) mouse monoclonal, ADK8, supernatantCat. No. 651160
anti-AAV8/9 (intact particle) mouse monoclonal, ADK8/9, supernatantCat. No. 651161

 

 

Neutralization epitope of the ADK9 Antibody

For AAV9 the neutralization epitope has been identified and might give an additional indication about the binding residues of the neutralizing antibody ADK9 used for the corresponding AAV9 Titration ELISAs.

anti-AAV-8/9 (intact particle) mouse monoclonal, ADK8/9 supernatantCat. No. 651161
anti-AAV9 (intact particle) mouse monoclonal, ADK9, supernatantCat. No. 651162
anti-AAV9 (intact particle) mouse monoclonal, ADK9, liquid, purifiedCat. No. 690162
anti-AAV9 (intact particle) mouse monoclonal, ADK9, liquid, purified, sampleCat. No. 690162S

anti-AAV9 (intact particle) mouse recombinant, ADK9-1R, lyophilized, purified

Cat. No. 610178

anti-AAV9 (intact particle) mouse recombinant, ADK9-1R, lyophilized, purified, sample

Cat. No. 610178S

Anti-Adeno-Associated Virus Particle Antibodies - Sample Size

The following antibodies are available in sample sizes of 10µg (lyophilized).

Potential Binding Sites of the ADK1a/1b Antibody

The ADK1a  antibody used for the AAV1 Titration ELISA as well as the ADK1b specifically recognize assembled AAV1 capsids, hence epitopes that result from a specific conformational assembly of the capsid proteins VP1, VP2 and VP3. In the publication cited below the contact sites and footprint residues identified for ADK1a and ADK1b are described and the results are summarized in table 1. Multiple contact sites and footprint residues have been identified, that are very likely to be part of the binding site. The amino acids of each binding site are located in different parts of the protein chains and are recognized as the epitope of the antibody only in the assembled capsid where they are in close proximity to each other and in the correct conformation.

Neutralization epitope of the ADK1 Antibody

For AAV1 the neutralization epitope has been identified and might give an additional indication about the binding residues of the neutralizing antibody ADK1 used for the corresponding AAV1 Titration ELISAs.

anti-AAV1 (intact particle) mouse monoclonal, ADK1a, lyophilized, purified, sampleCat. No. 610150S

Potential Binding Sites of the A20 Antibody

The A20 and A20R antibodies used for the AAV2 Titration ELISAs (PRATV & PRAAV2R) specifically recognize assembled AAV2 capsid, hence epitopes that result from a specific conformational assembly of the capsid proteins VP1, VP2 and VP3. Several publications cited below describe the analysis of binding sites for the A20 antibody using different techniques. Multiple amino acids have been identified, that are very likely to be part of the binding site, especially those that were identified with more than one method (green boxes). The amino acids of each binding site are located in different parts of the protein chains and are recognized as the epitope of the antibody only in the assembled capsid where they are in close proximity to each other and in the correct conformation.

anti-AAV2 (intact particle) mouse monoclonal, A20, lyophilized, purified, sampleCat. No. 61055S
anti-AAV2 (intact particle) mouse recombinant, A20R, lyophilized, purified, sampleCat. No. 610298S
anti-AAV4 (intact particle) mouse monoclonal, ADK4, lyophilized, purified, sampleCat. No. 610147S

Potential Binding Sites of the ADK5a/5b Antibody

The ADK5a  antibody used for the AAV5 Titration ELISA as well as the ADK5b specifically recognize assembled AAV5 capsids, hence epitopes that result from a specific conformational assembly of the capsid proteins VP1, VP2 and VP3. In the publication cited below the contact sites and footprint residues identified for ADK5a and ADK5b are described and the results are summarized in table 1. Multiple contact sites and footprint residues have been identified, that are very likely to be part of the binding site. The amino acids of each binding site are located in different parts of the protein chains and are recognized as the epitope of the antibody only in the assembled capsid where they are in close proximity to each other and in the correct conformation.

anti-AAV5 (intact particle) mouse monoclonal, ADK5a, lyophilized, purified, sampleCat. No. 610148S
anti-AAV5 (intact particle) mouse monoclonal, ADK5b, lyophilized, purified, sampleCat. No. 610149S
anti-AAV6 (intact particle) mouse monoclonal, ADK6, lyophilized, purified, sampleCat. No. 610159S

Potential Binding Sites of the ADK8 Antibody

The ADK8 antibody used for the AAV8 Titration ELISA (PRAAV8) specifically recognizes assembled AAV8 capsid, hence epitopes that result from a specific conformational assembly of the capsid proteins VP1, VP2 and VP3. The publication cited below shows the result of the Cryo-EM analysis of binding sites for the ADK8 antibody. In this publication one potential epitope has been identified which is likely to be part of the ADK8 binding site.

anti-AAV8 (intact particle) mouse monoclonal, ADK8, lyophilized, purified, sampleCat. No. 610160S

 

 

Neutralization epitope of the ADK9 Antibody

For AAV9 the neutralization epitope has been identified and might give an additional indication about the binding residues of the neutralizing antibody ADK9 used for the corresponding AAV9 Titration ELISAs.

anti-AAV9 (intact particle) mouse monoclonal, ADK9, lyophilized, purified, sampleCat. No. 690162S

anti-AAV9 (intact particle) mouse recombinant, ADK9-1R, lyophilized, purified, sample

Cat. No. 610178S

Anti-AAV Replicase proteins

The antibodies react with selected Rep (replicase) proteins in human AAV-infected cells.

anti-AAV2 Replicase mouse monoclonal, 76.2, lyophilized, purifiedCat. No. 61073
anti-AAV2 Replicase mouse monoclonal, 226.7, supernatantCat. No. 65172
anti-AAV2 Replicase mouse monoclonal, 259.5, lyophilized, purifiedCat. No. 61071
anti-AAV2 Replicase mouse monoclonal, 303.9, lyophylized, purifiedCat. No. 61069